TAP2 CLIA Kit for Human(Homo sapiens) | EIAab.comTAP2 CLIA Kit for Human(Homo sapiens)

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TAP2 (Gene name),

Antigen peptide transporter 2 (Protein name ), TAP2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

TAP2(ABCB3;PSF2;RING11;Y1);

Protein name:

Antigen peptide transporter 2(APT2);

Alternative:

Peptide supply factor 2;ATP-binding cassette sub-family B member 3;Peptide transporter TAP2;Peptide transporter PSF2(PSF-2);Really interesting new gene 11 protein;Peptide transporter involved in antigen processing 2;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterodimer of TAP1 and TAP2. Interacts with Epstein-Barr virus BLNF2a.

Function:

Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.

Subcellular Location:

Endoplasmic reticulum membrane Multi-pass membrane protein The transmembrane segments seem to form a pore in the membrane.

Protein Attributes:

Sequence length:

686

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

686:

RGDRTVLVIA | HRLQTVQRAH | QILVLQEGKL | QKLAQL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.502

Pfam:

PF00664

KEGG:

hsa:6891

STRING:

9606.ENSP00000372726

SMR:

Q03519

MIM:

170261

Uniprot:

Q03519

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ELISA Kit for Human APT2

Cat.:

E10018h

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96T

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ELISA Kit for Human APT2

Cat.:

E10018m

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96T

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ELISA Kit for Human APT2

Cat.:

E10018r

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CLIA Kit for Human APT2

Cat.:

U10018h

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96T

CLIA Kit for Human APT2

Cat.:

U10018m

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96T

CLIA Kit for Human APT2

Cat.:

U10018r

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96T

Polyclonal Antibody for Human APT2

Cat.:

P10018Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human APT2

Cat.:

P10018Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human APT2

Cat.:

P10018Rb-h

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40ug/0.2ml

Monoclonal Antibody for Human APT2

Protein for Human APT2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing."
Beck S. , Kelly A. , Radley E. , Khurshid F. , Alderton R.P. , Trowsdale J.
J. Mol. Biol.228:433-441(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE TAP2*01:01) (ISOFORM 1)
2.

"Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex."
Powis S.H. , Mockridge I. , Kelly A. , Kerr L.-A. , Glynne R.J. , Gileadi U. , Beck S. , Trowsdale J.
Proc. Natl. Acad. Sci. U.S.A.89:1463-1467(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE TAP2*01:01/TAP2*02:01) (ISOFORM 1)
3.

"Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region."
Bahram S. , Arnold D. , Bresnahan M. , Strominger J.L. , Spies T.
Proc. Natl. Acad. Sci. U.S.A.88:10094-10098(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE TAP2*02:01) (ISOFORM 1)
4.

"Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2."
Powis S.H. , Tonks S. , Mockridge I. , Kelly A.P. , Bodmer J.G. , Trowsdale J.
Immunogenetics37:373-380(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE TAP2*01:02) (ISOFORM 1)
5.

"Association of a new allele of the TAP2 gene, TAP2*Bky2 (Val577), with susceptibility to Sjogren's syndrome."
Kumagai S. , Kanagawa S. , Morinobu A. , Takada M. , Nakamura K. , Sugai S. , Maruya E. , Saji H.
Arthritis Rheum.40:1685-1692(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE TAP2*BKY2) (ISOFORM 1);VARIANT TAP2*BKY2 VAL-577
tissue: Blood.
6.

"Novel splicing of the human MHC-encoded peptide transporter confers unique properties."
Yan G. , Shi L. , Faustman D.
J. Immunol.162:852-859(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANT ILE-379
tissue: Spleen.
7.

"Evolutionary dynamics of non-coding sequences within the class II region of the human MHC."
Beck S. , Abdulla S. , Alderton R.P. , Glynne R.J. , Gut I.G. , Hosking L.K. , Jackson A. , Kelly A. , Newell W.R. , Sanseau P. , Radley E. , Thorpe K.L. , Trowsdale J.
J. Mol. Biol.255:1-13(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE TAP2*01:01) (ISOFORM 1)
8.

Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
Submitted (2005-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE TAP2*BKY2) (ISOFORM 1)
tissue: Liver.
tissue: Synovium.
9.

"The DNA sequence and analysis of human chromosome 6."
Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELES TAP2*03A AND TAP2*BKY2)
10.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
11.

"Novel human TAP2*103 allele shows further polymorphism in the ATP-binding domain."
Cano P. , Baxter-Lowe L.A.
Tissue Antigens45:139-142(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 65-686 (ALLELE TAP2*01:03) (ISOFORM 1)
tissue: Blood.
12.

"New TAP2 polymorphisms in Africans."
Tang J. , Allen S. , Karita E. , Musonda R. , Kaslow R.A.
Tissue Antigens51:556-562(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 204-686 (ISOFORM 1);VARIANTS THR-374 AND ILE-467
13.

Singal D.P. , Ye M. , D'Souza M.
Submitted (1993-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 517-645 (ALLELE TAP2*01:01/TAP2*01:02) (ISOFORM 1)
14.

"Polymorphisms in the TAP2 gene and their association with rheumatoid arthritis."
Singal D.P. , Ye M. , Qiu X. , D'Souza M.
Clin. Exp. Rheumatol.12:29-33(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 517-645 (ALLELE TAP2*01:01/TAP2*01:02) (ISOFORM 1)
15.

"Multiple regions of the transporter associated with antigen processing (TAP) contribute to its peptide binding site."
Nijenhuis M. , Hammerling G.J.
J. Immunol.157:5467-5477(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PEPTIDE-BINDING SITE
16.

"Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47."
Ahn K. , Meyer T.H. , Uebel S. , Sempe P. , Djaballah H. , Yang Y. , Peterson P.A. , Frueh K. , Tampe R.
EMBO J.15:3247-3255(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INHIBITION BY ICP47
17.

"The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP."
Ahn K. , Gruhler A. , Galocha B. , Jones T.R. , Wiertz E.J.H.J. , Ploegh H.L. , Peterson P.A. , Yang Y. , Frueh K.
Immunity6:613-621(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INHIBITION BY US6 GLYCOPROTEIN
18.

"The human cytomegalovirus gene product US6 inhibits ATP binding by TAP."
Hewitt E.W. , Gupta S.S. , Lehner P.J.
EMBO J.20:387-396(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INHIBITION BY US6 GLYCOPROTEIN
19.

"Adenovirus E19 has two mechanisms for affecting class I MHC expression."
Bennett E.M. , Bennink J.R. , Yewdell J.W. , Brodsky F.M.
J. Immunol.162:5049-5052(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INHIBITION BY E3-19K GLYCOPROTEIN
20.

"Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation."
Horst D. , van Leeuwen D. , Croft N.P. , Garstka M.A. , Hislop A.D. , Kremmer E. , Rickinson A.B. , Wiertz E.J.H.J. , Ressing M.E.
J. Immunol.182:2313-2324(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EBV BNLF2A
21.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
22.

"Allelic variants of the human putative peptide transporter involved in antigen processing."
Colonna M. , Bresnahan M. , Bahram S. , Strominger J.L. , Spies T.
Proc. Natl. Acad. Sci. U.S.A.89:3932-3936(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ILE-379 AND ALA-665
23.

"Homozygous human TAP peptide transporter mutation in HLA class I deficiency."
de la Salle H. , Hanau D. , Fricker D. , Urlacher A. , Kelly A. , Salamero J. , Powis S.H. , Donato L. , Bausinger H. , Laforet M. , Jeras M. , Spehner D. , Bieber T. , Falkenrodt A. , Cazenave J.-P. , Trowsdale J. , Tongio M.-M.
Science265:237-241(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN BLS1
24.

"Genotyping TAP2 variants in North American Caucasians, Brazilians, and Africans."
Tang J. , Freedman D.O. , Allen S. , Karita E. , Musonda R. , Braga C. , Jamieson B.D. , Louie L. , Kaslow R.A.
Genes Immun.2:32-40(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THR-374; ILE-379; ILE-467; SER-513 THR-565; CYS-651; ALA-665 AND GLN-GLU-GLY-GLN-ASP-LEU-TYR-SER-ARG-LEU-VAL-GLN-GLN-ARG-LEU-MET-ASP-686 INS;DEFINITION OF ALLELES

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